4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Base Information

Chemical Name:4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate
CAS No.:1093256-30-4
Molecular Formula:C₂HF₃O₂*C₂₂H₁₉Cl₃FN₃O₂
Molecular Weight:596.793
Hs Code.:

Synonyms:4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Suppliers and Price of 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

There total 15 articles about 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1093256-27-9
4-chloro-N-({4-chloro-3-[(3-chloro-5-ethenylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

: 76-05-1
trifluoroacetic acid

: 1093256-30-4
4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Guidance literature:: diazomethane; 4-chloro-N-({4-chloro-3-[(3-chloro-5-ethenylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide; bis(acetylacetonato)palladium(II); In diethyl ether; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

trifluoroacetic acid;

Reference yield:

: 145824-12-0
4-chloro-2-ethyl-1H-imidazole-5-carboxaldehyde

: 1093256-30-4
4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / propan-1-ol / 6 h / 100 °C

4: bis(acetylacetonato)palladium(II) / diethyl ether; dichloromethane / 24 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(acetylacetonato)palladium(II); In tetrahydrofuran; propan-1-ol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 146650-65-9
2-ethyl-4-chloro-5-(hydroxymethyl)-imidazole

: 1093256-30-4
4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide / 1,4-dioxane; dichloromethane / 6.5 h / Reflux

2: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 6 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / propan-1-ol / 6 h / 100 °C

5: bis(acetylacetonato)palladium(II) / diethyl ether; dichloromethane / 24 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(acetylacetonato)palladium(II); In tetrahydrofuran; 1,4-dioxane; propan-1-ol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;