(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

Base Information

Chemical Name:(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone
CAS No.:200629-37-4
Molecular Formula:C₁₉H₂₀N₂O₄
Molecular Weight:340.379
Hs Code.:

Synonyms:(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

Chemical Property:

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Technology Process of (4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

There total 4 articles about (4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 200629-37-4
(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / toluene / 24 h / Heating

2: NaOH, benzyltrimethylammonium chloride / H₂O; toluene / 19 h / Ambient temperature

3: aq. HCl / toluene / 20 h / Ambient temperature

4: 1.) NH₄OH, 2.) triethylamine, 3.) pyridine / 1.) water, toluene, room temperature, 18 h, 2.) THF, water, room temeperature, 4 d, 3.) room temperature, 22 h

With pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; benzyltrimethylammonium chloride; toluene-4-sulfonic acid; triethylamine; In water; toluene;
DOI:10.1021/jo971605p

Reference yield:

: 80500-11-4
N-(diphenylmethylene)-1-(pyridin-2-yl)methanamine

: 200629-37-4
(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH, benzyltrimethylammonium chloride / H₂O; toluene / 19 h / Ambient temperature

2: aq. HCl / toluene / 20 h / Ambient temperature

3: 1.) NH₄OH, 2.) triethylamine, 3.) pyridine / 1.) water, toluene, room temperature, 18 h, 2.) THF, water, room temeperature, 4 d, 3.) room temperature, 22 h

With pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; benzyltrimethylammonium chloride; triethylamine; In water; toluene;
DOI:10.1021/jo971605p

Reference yield:

: (3S,4R)-4-(Benzhydrylidene-amino)-3-(4-methoxy-phenyl)-4-pyridin-2-yl-butyric acid ethyl ester

: 200629-37-4
(4R,5S)-1-acetoxymethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / toluene / 20 h / Ambient temperature

2: 1.) NH₄OH, 2.) triethylamine, 3.) pyridine / 1.) water, toluene, room temperature, 18 h, 2.) THF, water, room temeperature, 4 d, 3.) room temperature, 22 h

With pyridine; hydrogenchloride; ammonium hydroxide; triethylamine; In toluene;
DOI:10.1021/jo971605p