2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

Base Information

Chemical Name:2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine
CAS No.:1620146-98-6
Molecular Formula:C₂₀H₁₄ClF₃N₄O₂
Molecular Weight:434.805
Hs Code.:

Synonyms:2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

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Chemical Property of 2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

Chemical Property:

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Technology Process of 2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

There total 3 articles about 2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 115204-74-5
2,6-dichloro-9-(4-methoxyphenylmethyl)-9H-purine

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1620146-98-6
2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In water; N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 1620146-98-6
2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1620146-98-6
2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.066