4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Base Information

• Chemical Name: 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide
• CAS No.: 1620147-05-8
• Molecular Formula: C₄₀H₃₉F₃N₈O₃
• Molecular Weight: 736.797
• Mol file: 1620147-05-8.mol

Synonyms:4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Chemical Property of 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

There total 10 articles about 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-amino-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide (1616369-01-7) + 2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine (1620146-98-6) → 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide (1620147-05-8)

Guidance literature:

With bismuth carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 150 ℃; for 3h; Microwave irradiation;

Reference yield:

N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-nitrobenzamide (1616369-00-6) → 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide (1620147-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

2,6-dichloro-9-(4-methoxyphenylmethyl)-9H-purine (115204-74-5) → 4-(9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide (1620147-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.066

upstream raw materials:

N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-nitrobenzamide

4-amino-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

2,6 dichloropurine

Downstream raw materials:

N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-(6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide