benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate
CAS No.:928038-54-4
Molecular Formula:C₄₀H₄₁F₂N₇O₆
Molecular Weight:753.806
Hs Code.:

benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

Synonyms:benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

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Chemical Property of benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

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Technology Process of benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

There total 10 articles about benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 688020-80-6
4-(4-piperidinyl)-1-piperazinecarboxylic acid,phenylmethyl ester

: 928038-09-9
phenyl N-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]-N-phenoxycarbonylcarbamate

: 928038-54-4
benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20.5h;

Reference yield:

: 864245-68-1
benzyl (4-((2-aminopyridin-4-yl)oxy)-2-fluorophenyl)carbamate

: 928038-54-4
benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 4 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 13.5 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 20.5 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 864245-67-0
4-(4-benzyloxycarbonylamino-3-fluorophenoxy)pyridine-2-carboxylic acid

: 928038-54-4
benzyl 4-{1-[4-(3-fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino }phenoxy)pyridin-2-ylcarbamoyl]piperidin-4-yl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; triethylamine / 5 h / 20 - 100 °C

2: hydrogenchloride / ethyl acetate / 3.67 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 1 h / 20 °C

4: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 4 h / 20 °C

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 13.5 h / 20 °C

6: triethylamine / N,N-dimethyl-formamide / 20.5 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;