tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

Base Information

Chemical Name:tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate
CAS No.:545434-84-2
Molecular Formula:C₈₀H₉₄N₆O₁₁
Molecular Weight:1315.66
Hs Code.:

tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

Synonyms:tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

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Chemical Property of tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

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Technology Process of tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

There total 7 articles about tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 153492-04-7
2-Hydroxy-1,2,3-propanetricarboxylic acid 2-tert-butyl 1,3-bis(p-nitrophenyl) triester

: 545434-83-1
N-{3-[(4-amino-butyl)-benzyl-amino]-propyl}-2,3-bis-benzyloxy-benzamide

: 545434-84-2
tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at -5 - 0 ℃;
DOI:10.1016/S0040-4020(03)00103-0

Reference yield:

: 90914-09-3
N⁽¹⁾-benzyl-N⁽⁴⁾-(tert-butyloxycarbonyl)-1,4-diaminobutane

: 545434-84-2
tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / methanol / 50 - 53 °C

2: 96 percent / H₂; NaOH / Raney Ni / ethanol; H₂O / 1520 - 2280 Torr

3: 74 percent / DIEA / CH₂Cl₂ / 20 °C

4: 73 percent / TFA / CH₂Cl₂; H₂O / 0 °C

5: 71 percent / DIEA / acetonitrile / -5 - 0 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(03)00103-0

Reference yield:

: 545434-80-8
{4-[benzyl-(2-cyano-ethyl)-amino]-butyl}-carbamic acid tert-butyl ester

: 545434-84-2
tert-butyl 4-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-[2-({4-[(3-{[2,3-bis(benzyloxy)benzoyl]amino}propyl)(phenylmethyl)amino]butyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂; NaOH / Raney Ni / ethanol; H₂O / 1520 - 2280 Torr

2: 74 percent / DIEA / CH₂Cl₂ / 20 °C

3: 73 percent / TFA / CH₂Cl₂; H₂O / 0 °C

4: 71 percent / DIEA / acetonitrile / -5 - 0 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; nickel; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(03)00103-0