Bis-benzyloxy benzoic acid

Base Information

• Chemical Name: Bis-benzyloxy benzoic acid
• CAS No.: 74272-78-9
• Molecular Formula: C21H18O4
• Molecular Weight: 334.372
• DSSTox Substance ID: DTXSID20441234
• Nikkaji Number: J1.357.897D
• Wikidata: Q82257912
• Mol file: 74272-78-9.mol

Synonyms:2,3-bis(benzyloxy)benzoic acid;74272-78-9;Bis-benzyloxy benzoic acid;2,3-dibenzyloxybenzoic acid;Benzoic acid, 2,3-bis(phenylmethoxy)-;2,3-bis(phenylmethoxy)benzoic Acid;SCHEMBL1305739;DTXSID20441234;GYEYPHBTKAEWHH-UHFFFAOYSA-N;MFCD27939890;FT-0725131;D84396;WLB

Chemical Property of Bis-benzyloxy benzoic acid

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 334.12050905
• Heavy Atom Count: 25
• Complexity: 399

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2OCC3=CC=CC=C3)C(=O)O

Technology Process of Bis-benzyloxy benzoic acid

There total 14 articles about Bis-benzyloxy benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 2,3-bis(benzyloxy)benzoate (95922-26-2) → 2,3-dibenzyloxybenzoic acid (74272-78-9)

Guidance literature:

With sodium hydroxide; In methanol; for 3h; Reflux;

DOI:10.1002/chem.201301825

Reference yield: 100.0%

Methyl 2,3-bis(benzyloxy)benzoate (2169-27-9) → 2,3-dibenzyloxybenzoic acid (74272-78-9)

Guidance literature:

With barium dihydroxide; In tetrahydrofuran; at 50 ℃; for 12h;

DOI:10.1016/j.tetlet.2007.02.125

Reference yield: 95.0%

2,3-bis(benzyloxy)benzaldehyde (5779-91-9) → 2,3-dibenzyloxybenzoic acid (74272-78-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetonitrile; tert-butyl alcohol; at 0 - 20 ℃; for 2h;

upstream raw materials:

2,3-bis(benzyloxy)benzaldehyde

Methyl 2,3-bis(benzyloxy)benzoate

2,3-Dihydroxybenzoic acid

benzyl bromide

Downstream raw materials:

2,3-bis(benzyloxy)-1-((2-thioxothiazolidin-1-yl)carbonyl)benzene

N¹,N⁸-bis(2,3-dibenzyloxybenzoyl)-N⁴-(4-nitrobenzyloxycarbonyl)-spermidine

2,3-bis(benzyloxy)benzoyl chloride

2,3-bis(benzyloxy)-N-(3-(4-(2,3-bis(benzyloxy)benzamido)butylamino)propyl)benzamide