4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

Base Information

• Chemical Name: 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile
• CAS No.: 117601-23-7
• Molecular Formula: C₁₇H₁₆N₂OS
• Molecular Weight: 296.393

Synonyms:4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

Chemical Property of 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

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Technology Process of 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

There total 5 articles about 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-methoxybenzylidenecyanothioacetamide (106763-17-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (117601-23-7)

Guidance literature:

With piperidine; In 1,4-dioxane; for 3h; Heating;

DOI:10.1016/S0040-4020(01)81038-3

Reference yield: 45.0%

E-2-(4-methoxybenzylidene)cyclohexanone (5765-29-7,37722-53-5) + Cyanothioacetamide (7357-70-2) → 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (117601-23-7)

Guidance literature:

With sodium methylate; In methanol; at 50 ℃; for 48h;

Reference yield: 43.0%

4-(4-methoxyphenyl)-2-oxo-1,2,3,4,5,6,7,8-octahydroquinoline-3-carbonitrile → 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (117601-23-7)

Guidance literature:

With tetraphosphorus decasulfide; In toluene; for 4h; Reflux;

DOI:10.1002/jhet.3046

upstream raw materials:

E-2-(4-methoxybenzylidene)cyclohexanone

Cyanothioacetamide

4-methoxybenzylidenecyanothioacetamide

cyclohexanone

Downstream raw materials:

2-Cyanomethylsulfanyl-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid methyl ester

[3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester

3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid amide

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