2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1393900-60-1
Molecular Formula:C₂₅H₂₆F₃N₅O₂
Molecular Weight:485.509
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 20 articles about 2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1393901-45-5
tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

: 1393900-60-1
2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate; With trifluoroacetic acid; In dichloromethane; for 18h;

With sodium hydroxide; In water;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1393900-60-1
2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate; methanol / 3 h / 20 °C / Cooling with ice

1.2: 16 h / 20 °C

2.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 1,4-dioxane / 4 h / 90 °C

3.1: sodium hydride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 17 h / 20 °C / Cooling with ice

4.1: hydrogen bromide; acetic acid; phenol / 12 h / 75 °C / sealed tube; microwave irradiation

5.1: dmap / dichloromethane / 1 h

6.1: hydrazine hydrate / iron(III) chloride hexahydrate / methanol / 5 h / Reflux

6.2: 7 h / Reflux

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.2: pH 3

9.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 18 h

With methanol; sodium tetrahydroborate; hydrazine hydrate; lithium hydroxide monohydrate; N-benzyl-N,N,N-triethylammonium chloride; water; hydrogen bromide; ammonium carbonate; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; phenol; dmap; iron(III) chloride hexahydrate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393900-60-1
2-(2-(2-(2-((4-(morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.17 h / 100 °C / microwave irradiation

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.2: pH 3

9.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 18 h

With lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; ammonium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;