tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Chemical Name:tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate
CAS No.:1393901-45-5
Molecular Formula:C₃₀H₃₄F₃N₅O₄
Molecular Weight:585.626
Hs Code.:

Synonyms:tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Chemical Property of tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Technology Process of tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

There total 19 articles about tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1393901-44-4
2-(2-(2-(2-((4-(4-(tert-butoxycarbonyl)morpholin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

: 1393901-45-5
tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: With ammonium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1393901-45-5
tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tetrahydroborate; methanol / 3 h / 20 °C / Cooling with ice

1.2: 16 h / 20 °C

2.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 1,4-dioxane / 4 h / 90 °C

3.1: sodium hydride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 17 h / 20 °C / Cooling with ice

4.1: hydrogen bromide; acetic acid; phenol / 12 h / 75 °C / sealed tube; microwave irradiation

5.1: dmap / dichloromethane / 1 h

6.1: hydrazine hydrate / iron(III) chloride hexahydrate / methanol / 5 h / Reflux

6.2: 7 h / Reflux

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.2: pH 3

9.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With methanol; sodium tetrahydroborate; hydrazine hydrate; lithium hydroxide monohydrate; N-benzyl-N,N,N-triethylammonium chloride; water; hydrogen bromide; ammonium carbonate; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; phenol; dmap; iron(III) chloride hexahydrate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393901-45-5
tert-butyl 2-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.17 h / 100 °C / microwave irradiation

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.2: pH 3

9.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; ammonium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;