(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Base Information

Chemical Name:(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene
CAS No.:292046-29-8
Molecular Formula:C₂₀H₃₃IO₃Si
Molecular Weight:476.47
Hs Code.:

Synonyms:(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Suppliers and Price of (Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

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Chemical Property of (Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Chemical Property:

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Technology Process of (Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

There total 3 articles about (Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197219-15-1
6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol

: 292046-29-8
(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH₂Al(OCH₂CH₂OMe)2 / diethyl ether

1.2: I₂ / diethyl ether

2.1: Et₃N; DMAP / CH₂Cl₂

With dmap; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; dichloromethane; 1.1: complex formation / 1.2: Iodination / 2.1: silylation;
DOI:10.1016/S0040-4039(00)00719-X

Reference yield:

: 198411-17-5
1-((3-iodopropoxy)methyl)-4-methoxybenzene

: 292046-29-8
(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -25 - 20 °C

2.1: PPTS / methanol / Heating

3.1: NaH₂Al(OCH₂CH₂OMe)2 / diethyl ether

3.2: I₂ / diethyl ether

4.1: Et₃N; DMAP / CH₂Cl₂

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 1.1: Alkylation / 2.1: dealkenylation / 3.1: complex formation / 3.2: Iodination / 4.1: silylation;
DOI:10.1016/S0040-4039(00)00719-X

Reference yield:

: 2-[6-(4-methoxy-benzyloxy)-hex-2-ynyloxy]-tetrahydro-pyran

: 292046-29-8
(Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPTS / methanol / Heating

2.1: NaH₂Al(OCH₂CH₂OMe)2 / diethyl ether

2.2: I₂ / diethyl ether

3.1: Et₃N; DMAP / CH₂Cl₂

With dmap; pyridinium p-toluenesulfonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; diethyl ether; dichloromethane; 1.1: dealkenylation / 2.1: complex formation / 2.2: Iodination / 3.1: silylation;
DOI:10.1016/S0040-4039(00)00719-X