diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate

Base Information

• Chemical Name: diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate
• CAS No.: 1401467-17-1
• Molecular Formula: C₂₄H₂₉O₄P
• Molecular Weight: 412.466
• Mol file: 1401467-17-1.mol

Synonyms:diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate

Chemical Property of diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate

There total 3 articles about diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetralin-1-carboxylic acid (1914-65-4) → diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate (1401467-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: 20 °C / Cooling with ice

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C

With oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201203092

Reference yield:

C15H21O4P + Cinnamyl bromide (4392-24-9) → diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate (1401467-17-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/anie.201203092

Reference yield:

1,2,3,4-tetrahydronaphthalene-1-carbonyl chloride (50341-99-6) → diethyl (E)-cinnamyloxy(3,4-dihydronaphthalen-1(2H)-ylidene)methylphosphonate (1401467-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 °C / Cooling with ice

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1002/anie.201203092

upstream raw materials:

Cinnamyl bromide

tetralin-1-carboxylic acid

1,2,3,4-tetrahydronaphthalene-1-carbonyl chloride

Downstream raw materials:

(R)-1-((R)-1-phenylallyl)-1,2,3,4-tetrahydronaphthalene-1-carbonylphosphonate