1914-65-4

Basic information

• Product Name: 1,2,3,4-Tetrahydro-1-naphthoic acid
• Synonyms: 1,2,3,4-TETRAHYDRO-1-NAPHTHOIC ACID;1,2,3,4-TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID;1,2,3,4-TETRAHEDRO-NAPHTHOIC ACID;1-Tetralincarboxylic acid;1,2,3,4-TETRAHYDRO-1-NAPHTHOIC;1,2,3,4-tetrahydro-naphthoic acid;1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro;1,2,3,4-Tetrahydro-1-naphtholic acid
• CAS NO: 1914-65-4
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• EINECS: 1806241-263-5
• Product Categories: Pharmaceutical material and intermeidates;Benzocycles;INTERMEDIATESOFPALONOSETRONHYDROCHLORIDE;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1914-65-4.mol
• Article Data: 20

Chemical Properties

• Melting Point: 75-77°C
• Boiling Point: 135°C/5mmHg(lit.)
• Flash Point: 156.408 °C
• Appearance: /
• Density: 1.186 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Refrigerator
• Solubility: Soluble in methanol, and chloroform.
• PKA: 4.28±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-1-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-1-naphthoic acid(1914-65-4)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-1-naphthoic acid(1914-65-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-51
• Safety Statements: 26
• Hazardous Substances Data: 1914-65-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 1914-65-4 differently. You can refer to the following data:
1. 1,2,3,4-Tetrahydro-1-naphthoic acid is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid is a reagent used to produce protease inhibitors.
2. 1,2,3,4-Tetrahydro-1-naphthoic acid is a reagent used to produce protease inhibitors.

InChI:InChI=1/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)

Upstream product

• 3123-46-4 4-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 64985-86-0 1-naphthoic anhydride 
• 132205-64-2 1-cyanotetraline 
• 86-55-5 1-naphthalenecarboxylic acid 
• 71-41-0 pentan-1-ol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 19692-24-1 4-ethoxy-1-naphthoic acid 
• 3333-23-1 3,4-dihydronaphthalene-1-carboxylic acid 
• 67260-13-3 1,2,3,4-tetrahydronaphthalene-1-ketene 
• 634892-57-2 2-methyl-5-(1,2,3,4-tetrahydro-1-naphthyl)furan 
• 23357-47-3 (R)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 124-38-9 carbon dioxide 
• 23357-52-0 (S)-1,2,3,4-tetrahydronapht-1-yl-amine 
• 447-53-0 1,2-Dihydronaphthalene 

Downstream Products

• 86346-43-2 1,2,3,4-tetrahydro-[2]naphthoyl chloride 
• 66041-55-2 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester 
• 85977-52-2 (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 23357-47-3 (R)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 50341-99-6 1,2,3,4-tetrahydronaphthalene-1-carbonyl chloride 
• 104116-25-8 4-bromo-1,2,3,4-tetrahydro-[1]naphthoic acid 
• 63979-18-0 1,2,3,4-tetrahydro-[1]naphthoic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 70884-74-1 p-ethoxycarbonylphenyl 7-nitro-1,2,3,4-tetrahydro-1-naphthoate 
• 70884-48-9 p-ethoxycarbonylphenyl 5-nitro-1,2,3,4-tetrahydro-1-naphthoate 
• 7384-42-1 decalin-1-carboxylic acid 
• 107424-67-9 1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid phenyl ester 
• 75481-12-8 5-nitro-1,2,3,4-tetrahydro-1-naphthoic acid 
• 75481-13-9 7-nitro-1,2,3,4-tetrahydro-1-naphthoic acid 
• 70884-88-7 phenyl 5-amino-1,2,3,4-tetrahydro-1-naphthoate * HCl 

Relevant articles and documents

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Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions

A range of hitherto unexplored biomass-derived chemicals have been evaluated as new sustainable solvents for a large variety of CO2-based carboxylation reactions. Known biomass-derived solvents (biosolvents) are also included in the study and the results are compared with commonly used solvents for the reactions. Biosolvents can be efficiently applied in a variety of carboxylation reactions, such as Cu-catalyzed carboxylation of organoboranes and organoboronates, metal-catalyzed hydrocarboxylation, borocarboxylation, and other related reactions. For many of these reactions, the use of biosolvents provides comparable or better yields than the commonly used solvents. The best biosolvents identified are the so far unexplored candidates isosorbide dimethyl ether, acetaldehyde diethyl acetal, rose oxide, and eucalyptol, alongside the known biosolvent 2-methyltetrahydrofuran. This strategy was used for the synthesis of the commercial drugs Fenoprofen and Flurbiprofen.

Electrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochemical reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.