N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

Base Information

Chemical Name:N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol
CAS No.:137591-96-9
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

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Technology Process of N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

There total 5 articles about N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 137591-95-8
N-<7-(2-Pyridyl)-7-aminoheptyl>-5-methoxy-3-methyl-2-(4-methoxyphenyl)-indol

: 137591-96-9
N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

Guidance literature:: With boron tribromide; In dichloromethane; 1) -78 deg C, 3 h 2) r.t., 20 h 3) reflux, 2 h;
DOI:10.1002/ardp.2503241003

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 137591-96-9
N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH / 1) DMF, 0 deg C, 1 h 2) 0 deg C, 1 h 3) r.t., 3 h

2: 1) Lithiumdiisopropylamid / 1) THF, -78 deg C, 30 min 2) THF, -78 deg C, 10 h 3) r.t., 10 h

3: 91 percent / NH₂OH*HCl, NaOH / ethanol; H₂O / 12 h / Heating

4: 45 percent / Zn, 25percent NH₃ / ethanol / 5 h / Heating

5: 57 percent / BBr₃ / CH₂Cl₂ / 1) -78 deg C, 3 h 2) r.t., 20 h 3) reflux, 2 h

With ammonium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; boron tribromide; sodium hydride; zinc; lithium diisopropyl amide; In ethanol; dichloromethane; water;
DOI:10.1002/ardp.2503241003

Reference yield:

: 21086-33-9
2-bromo-1-(4-methoxyphenyl)-1-propanone

: 137591-96-9
N-<7-(2-Pyridyl)-7-aminoheptyl>-5-hydroxy-3-methyl-2-(4-hydroxyphenyl)-indol

Guidance literature:: Multi-step reaction with 6 steps

1: 41 percent / N,N-Dimethylanilin / xylene / 2 h / 180 °C

2: 1) NaH / 1) DMF, 0 deg C, 1 h 2) 0 deg C, 1 h 3) r.t., 3 h

3: 1) Lithiumdiisopropylamid / 1) THF, -78 deg C, 30 min 2) THF, -78 deg C, 10 h 3) r.t., 10 h

4: 91 percent / NH₂OH*HCl, NaOH / ethanol; H₂O / 12 h / Heating

5: 45 percent / Zn, 25percent NH₃ / ethanol / 5 h / Heating

6: 57 percent / BBr₃ / CH₂Cl₂ / 1) -78 deg C, 3 h 2) r.t., 20 h 3) reflux, 2 h

With ammonium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; boron tribromide; sodium hydride; N,N-dimethyl-aniline; zinc; lithium diisopropyl amide; In ethanol; dichloromethane; water; xylene;
DOI:10.1002/ardp.2503241003