5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

Base Information

Chemical Name:5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole
CAS No.:1093304-16-5
Molecular Formula:C₂₂H₂₃N₅O
Molecular Weight:373.458
Hs Code.:

Synonyms:5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

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Chemical Property of 5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

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Technology Process of 5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

There total 6 articles about 5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093307-23-3
1-(5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-5-o-tolyl-1H-1,2,3-triazol-4-yl)-1H-indazol-1-yl)ethanone

: 1093304-16-5
5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

Guidance literature:: With potassium hydroxide; water; In tetrahydrofuran; methanol; for 3h;

Reference yield:

: 101691-94-5
4-(iodomethyl)tetrahydro-2H-pyran

: 1093304-16-5
5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / dimethyl sulfoxide / 20 °C

2.1: 2 h / 70 °C

2.2: 130 °C

3.1: copper(I) thiophene-2-carboxylate / bis-triphenylphosphine-palladium(II) chloride / toluene / 0.33 h / 150 °C

4.1: potassium hydroxide; water / tetrahydrofuran; methanol / 3 h

With potassium hydroxide; sodium azide; copper(I) thiophene-2-carboxylate; water; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;

Reference yield:

: 1035490-93-7
4-(azidomethyl)tetrahydropyrane

: 1093304-16-5
5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2 h / 70 °C

1.2: 130 °C

2.1: copper(I) thiophene-2-carboxylate / bis-triphenylphosphine-palladium(II) chloride / toluene / 0.33 h / 150 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 3 h

With potassium hydroxide; copper(I) thiophene-2-carboxylate; water; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; toluene;