N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

Base Information

Chemical Name:N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid
CAS No.:1059182-80-7
Molecular Formula:C₂₆H₂₄F₃NO₅
Molecular Weight:487.475
Hs Code.:

Synonyms:N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

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Chemical Property of N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

Chemical Property:

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Technology Process of N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

There total 5 articles about N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059182-79-4
N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid benzyl ester

: 1059182-80-7
N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 1059182-78-3
(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

: 1059182-80-7
N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 16 h / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1059182-80-7
N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 16 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide;