N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Base Information

Chemical Name:N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide
CAS No.:1059182-10-3
Molecular Formula:C₂₇H₂₇F₃N₂O₄
Molecular Weight:500.518
Hs Code.:

Synonyms:N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Suppliers and Price of N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

There total 6 articles about N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1059182-80-7
N-(3,4-dimethoxyphenyl)-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid

: 74-89-5
methylamine

: 1059182-10-3
N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: With pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1059182-78-3
(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

: 1059182-10-3
N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 16 h / 20 °C

3: pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1059182-10-3
N-(3,4-dimethoxyphenyl)-N'-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: Multi-step reaction with 5 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 16 h / 20 °C

5: pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide;