1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea

Base Information

• Chemical Name: 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea
• CAS No.: 1342827-08-0
• Molecular Formula: C₂₈H₂₇FN₄O₃S
• Molecular Weight: 518.612
• Mol file: 1342827-08-0.mol

Synonyms:1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea

Chemical Property of 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea

There total 3 articles about 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(pyrrolidin-1-yl)methanone (1342834-49-4) + Isopropyl isocyanate (1795-48-8) → 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea (1342827-08-0)

Guidance literature:

In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid (389621-81-2) → 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea (1342827-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1: cesium fluoride; sodium carbonate / Pd(PPh₃)Cl₂ / 1,2-dimethoxyethane; water

2: ammonium chloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

3: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With ammonium chloride; sodium carbonate; cesium fluoride; Pd(PPh₃)Cl₂; In 1,2-dimethoxyethane; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

(4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(pyrrolidin-1-yl)methanone (1342834-47-2) → 1-(3-fluoro-4-(2-(4-(pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-isopropylurea (1342827-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With ammonium chloride; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

upstream raw materials:

(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(pyrrolidin-1-yl)methanone

Isopropyl isocyanate

[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

(4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(pyrrolidin-1-yl)methanone