1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

Base Information

Chemical Name:1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea
CAS No.:1039733-99-7
Molecular Formula:C₂₅H₂₅FN₆O
Molecular Weight:444.512
Hs Code.:

Synonyms:1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

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Chemical Property of 1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

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Technology Process of 1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

There total 4 articles about 1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1039736-34-9
N-(4-flourophenyl)-N'-[4-({[2-(chloro)-6-methylquinazolin-4-yl]amino}methyl)phenyl]urea

: 506-59-2
N,N-dimethylammonium chloride

: 1039733-99-7
1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

Guidance literature:: In tetrahydrofuran; isopropyl alcohol; for 12h; Heating / reflux;

Reference yield:

: 926239-00-1
N-[4-(aminomethyl)phenyl]-N'-(4-fluorophenyl)urea

: 1039733-99-7
1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

2: tetrahydrofuran; isopropyl alcohol / 12 h / Heating / reflux

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1039733-99-7
1N-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]-N'-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 24 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

3: tetrahydrofuran; isopropyl alcohol / 12 h / Heating / reflux

With triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;