3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde
• CAS No.: 308298-47-7
• Molecular Formula: C₁₈H₁₆N₂OS
• Molecular Weight: 308.404
• Mol file: 308298-47-7.mol

Synonyms:3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde

Chemical Property of 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde

There total 2 articles about 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) + para-thiocresol (106-45-6) → 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde (308298-47-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

DOI:10.1039/c7nj01962a

Reference yield:

edaravone (89-25-8) → 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde (308298-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1 h / 0 - 90 °C

1.2: Cooling

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b00033

Reference yield: 91.0%

2-Acetylthiazole (24295-03-2,260998-74-1) + 3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde (308298-47-7) + 1,3-benzothiazol-2-ylhydrazine (615-21-4) → 2-{5′-methyl-3′-[(4-methylphenyl)sulfanyl]-1′-phenyl-5-(1,3-thiazol-2-yl)-3,4-dihydro-1′H,2H-[3,4′-bipyrazol]-2-yl}-1,3-benzothiazole

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 0.05h; Sonication;

DOI:10.1134/S1070428021100225

upstream raw materials:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

para-thiocresol

edaravone

Downstream raw materials:

C₁₈H₁₇N₃OS