89-25-8Relevant academic research and scientific papers
Structure and extractive ability of 1-alkyl- and 3-methyl-1-phenyl-2- pyrazolin-5-ones
Lesnov,Sazonova,Pavlov
, p. 298 - 302 (2005)
Extractive ability of 1-substituted 3-methylpyrazol-5-ones (LH) is studied. From acidic chloride complexes, ionic thallium(III) associates (LH 2)[TlCl4] are extracted; from trichloroacetate, coordination scandium complexes Sc(LH)4(CCl3COO) 3; and from ammine, copper(II) complexes CuL2. The extractive ability decreases in the order R = C7H15 > C6H13 > C5H11 > C 6H5 > C4H9. 2005 Pleiades Publishing, Inc.
Synthesis and crystal structure of 5-chloro-3-methyl-1-phenyl-1H-pyrazole- 4-carbaldehyde
Xu, Cun-Jin,Shi, Yan-Qin
, p. 1816 - 1819 (2011)
The title compound, 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 2, was prepared in a series of syntheses to produce new pyrazole derivatives, and its crystal structure was determined by X-ray diffraction method. The crystal belongs to monoclinic
Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-methyl-1-substituted-1H-pyrazoles
Kang, Jing,Yue, Xia Li,Chen, Chang Shui,Li, Jian Hong,Ma, Hong Ju
, (2016)
With the objective of finding valuable herbicidal candidates, a series of new 5-heterocycloxy- 3-methyl-1-substituted-1H-pyrazoles were synthesized and their herbicidal activities were evaluated. The bioassay results showed that some compounds exhibited e
Click inspired novel pyrazole-triazole-persulfonimide & pyrazole-triazole-aryl derivatives; Design, synthesis, DPP-4 inhibitor with potential anti-diabetic agents
Nidhar, Manisha,Khanam, Shaziya,Sonker, Priyanka,Gupta, Priya,Mahapatra, Archisman,Patil, Swaraj,Yadav, Brijesh Kumar,Singh, Rahul Kumar,Kumar Tewari, Ashish
supporting information, (2022/01/22)
This work presented the first report on designing, synthesizing of novel pyrazole-triazole-persulfonimide (7a-i) and pyrazole-triazole-aryl derivatives (8a-j) via click reaction using CuI catalyst and evaluated for their anti-diabetic activity and DPP-4 i
Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones
Wang, Rong-Hui,Li, Ya-Ling,He, Hong-Jiao,Xiao, You-Cai,Chen, Fen-Er
supporting information, p. 4302 - 4306 (2021/02/16)
The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.
Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
Fang, Feifei,Han, Xu,Hu, Shulei,Li, Chunpu,Liu, Hong,Wang, Qian,Wang, Run,Zhou, Yu
supporting information, p. 21327 - 21333 (2021/08/20)
A catalytic system-controlled divergent reaction strategy was here reported to construct four types of intriguing spiroheterocyclic skeletons from simple and readily available starting materials via a precise chemical bond activation/[n+1] annulation cascade. The tetraazaspiroheterocyclic and trizazspiroheterocyclic scaffolds could be independently constructed by a selective N?N bond activation/[n+1] annulation cascade, a C(sp2)-H activation/[4+1] annulation and a novel tandem C(sp2)-H/C(sp3)?H bond activation/[4+1] annulation strategy, along with a broad scope of substrates, moderate to excellent yields and valuable transformations. More importantly, in these transformations, we are the first time to capture a N?N bond activation and a C(sp3)?H bond activation of pyrazolidinones under different catalytic system.
Preparative, mechanistic and tautomeric investigation of 1-phenyl and 1-methyl derivative of 3-methyl-5-pyrazolone
Fakhraian, Hossein,Nafari, Yaser
, (2021/04/19)
1-Phenyl and 1-methyl derivative of 3-methyl-5-pyrazolone were prepared quantitatively via a scalable solvent-free reaction of corresponding hydrazine derivative with ethyl acetoacetate. Different mechanisms have been proposed for the reaction of hydrazine derivatives (methyl or phenyl) with ethyl acetoacetate and also the tautomeric aspects of the targeted compounds have been discussed. Graphical abstract: [Figure not available: see fulltext.] Synopsis: 13C NMR and quantitative proportional amount of different tautomeric forms of 1,3-dimethyl-5-pyrazolone in DMSO-d6.
Edaravone preparation method
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Paragraph 0014; 0026-0045, (2021/10/27)
To the preparation method of edaravone, hydrazine and ethyl acetoacetate are taken as raw materials to carry out cyclization reaction under a solvent-free condition, and water is reduced. The acetic acid, absolute ethyl alcohol and other solvents are intr
Edaravone preparation method
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Paragraph 0026-0042, (2021/11/26)
The edaravone preparation method comprises the following steps: S1) mixing phenylhydrazine and ethyl acetoacetate, and carrying out solvent-free reaction. S2) After the end of the reaction. A solvent is added to the reaction system for crystallization and
Design, synthesis, antibacterial evaluation and molecular docking studies of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives
Depa, Navaneetha,Erothu, Harikrishna
, p. 1087 - 1098 (2021/02/26)
The development of new antimicrobial drugs is most needed due to rapid growth in global antimicrobial resistance. Thus, in this context, a series of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives (7a–j) was synthesized. All the derivatives we
