(R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester

Base Information

• Chemical Name: (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester
• CAS No.: 1197031-90-5
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 1197031-90-5.mol

Synonyms:(R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester

Chemical Property of (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester

There total 2 articles about (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-Methylhydrazinecarboxylic acid,1,1-dimethylethyl ester (127799-54-6) + (S)-methyl 2-hydroxy-3-phenylpropanoate (13673-95-5) → (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester (1197031-90-5)

Guidance literature:

(S)-methyl 2-hydroxy-3-phenylpropanoate; With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.25h;

2-Methylhydrazinecarboxylic acid,1,1-dimethylethyl ester; In dichloromethane; at 0 ℃; for 4.5h;

DOI:10.1016/j.tetlet.2009.08.095

Reference yield:

2-Methylhydrazinecarboxylic acid,1,1-dimethylethyl ester (127799-54-6) + methyl (L)-3-phenyllactate triflate (84028-86-4) → (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinophenylalanine methyl ester (1197031-90-5)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2012.04.018

upstream raw materials:

2-Methylhydrazinecarboxylic acid,1,1-dimethylethyl ester

(S)-methyl 2-hydroxy-3-phenylpropanoate

methyl (L)-3-phenyllactate triflate