N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester

Base Information

• Chemical Name: N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester
• CAS No.: 83030-91-5
• Molecular Formula: C₆₅H₇₇N₁₃O₁₄
• Molecular Weight: 1264.41

Synonyms:N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester

Chemical Property of N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester

There total 16 articles about N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-4-methanol (586-95-8) → Nα-benzyloxycarbonyl-Nω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester (83030-91-5)

Guidance literature:

Multi-step reaction with 15 steps

1: 81 percent / dicyclohexylcarbodi-imide

2: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C_. 5 min

3: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

4: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

5: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

6: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

7: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

8: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

9: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

10: 1.) trifluoroacetic acid, 2.) N_.N-di-isopropylethylamine / 1.) 0 deg C, 5 min

11: dicyclohexylcarbodi-imide, 1-hydroxybenzotrizole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

12: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

13: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / 0 deg C, 1 h; room temperature, 1 h, pH 4.5-5.0

14: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

15: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole hydrate / dimethylformamide / 0 deg C, 1 h; room temperature, 1h, pH 4.5-5.0

With benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

L-phenylalanine 4-picolyl ester (84891-23-6) → Nα-benzyloxycarbonyl-Nω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester (83030-91-5)

Guidance literature:

Multi-step reaction with 13 steps

1: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

2: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

3: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

4: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

5: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

6: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

7: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

8: 1.) trifluoroacetic acid, 2.) N_.N-di-isopropylethylamine / 1.) 0 deg C, 5 min

9: dicyclohexylcarbodi-imide, 1-hydroxybenzotrizole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

10: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

11: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / 0 deg C, 1 h; room temperature, 1 h, pH 4.5-5.0

12: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

13: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole hydrate / dimethylformamide / 0 deg C, 1 h; room temperature, 1h, pH 4.5-5.0

With benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Nα-benzyloxycarbonyl-Nω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester (83030-91-5)

Guidance literature:

Multi-step reaction with 15 steps

1: 81 percent / dicyclohexylcarbodi-imide

2: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C_. 5 min

3: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

4: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

5: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

6: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

7: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

8: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

9: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

10: 1.) trifluoroacetic acid, 2.) N_.N-di-isopropylethylamine / 1.) 0 deg C, 5 min

11: dicyclohexylcarbodi-imide, 1-hydroxybenzotrizole, pH 4.5-5.0 / 0 deg C, 1 h; room temperature, 1 h

12: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

13: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / 0 deg C, 1 h; room temperature, 1 h, pH 4.5-5.0

14: 1.) trifluoroacetic acid, 2.) N,N-di-isopropylethylamine / 1.) 0 deg C, 5 min

15: dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole hydrate / dimethylformamide / 0 deg C, 1 h; room temperature, 1h, pH 4.5-5.0

With benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

(S)-2-[((S)-1-{(S)-3-Benzyloxy-2-[(S)-3-phenyl-2-(2-{[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-propionylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid pyridin-4-ylmethyl ester

N^α-benzyloxycarbonyl-N^ω-nitro-L-arginine

pyridine-4-methanol

L-phenylalanine 4-picolyl ester

Downstream raw materials:

N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 83030-91-5 N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-O-benzyl-L-seryl-L-prolyl-L-phenylalanine 4-picolyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send