tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

Base Information

Chemical Name:tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate
CAS No.:870843-26-8
Molecular Formula:C₂₁H₂₇ClN₂O₃
Molecular Weight:390.91
Hs Code.:

Synonyms:tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

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Chemical Property of tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

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Technology Process of tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

There total 9 articles about tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870837-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

: 870843-25-7
5-chloro-2-(diethoxyphosphoryl)valeric acid tert-butyl ester

: 870843-26-8
tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield:

: 870837-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

: 870843-25-7
5-chloro-2-(diethoxyphosphoryl)valeric acid tert-butyl ester

: 870843-26-8
tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

: C₂₁H₂₇ClN₂O₃

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -5 - 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02979

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 870843-26-8
tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran

2: lithium hydroxide / tetrahydrofuran

With sodium hydride; lithium hydroxide; In tetrahydrofuran; 2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2012.11.055