(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Base Information

Chemical Name:(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate
CAS No.:870850-40-1
Molecular Formula:C₂HF₃O₂*C₁₇H₁₉ClN₂O₃
Molecular Weight:448.826
Hs Code.:

Synonyms:(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Suppliers and Price of (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

There total 8 articles about (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870843-26-8
tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

: 870850-40-1
(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 870843-26-8
tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate

: 76-05-1
trifluoroacetic acid

: 870850-40-1
(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 870837-20-0
4-[formyl-(2-oxopropyl)amino]-3-methoxybenzoic acid methyl ester

: 870850-40-1
(E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; ammonium acetate / water / Inert atmosphere

2.1: Red-Al / tetrahydrofuran; toluene / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / -5 - 0 °C / Inert atmosphere

4.1: dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

With potassium tert-butylate; ammonium acetate; acetic acid; In tetrahydrofuran; dichloromethane; water; toluene; 3.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/acs.joc.6b02979