4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1403889-33-7
Molecular Formula:C₁₃H₁₁Cl₂N₅O₂S
Molecular Weight:372.235
Hs Code.:

Synonyms:4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 3 articles about 4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1403889-29-1
2-[4-(3,5-dichlorophenyl)-3-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide

: 1403889-33-7
4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: 2-[4-(3,5-dichlorophenyl)-3-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide; With potassium hydroxide; In ethanol; water; at 100 ℃; for 0.0833333h; Microwave irradiation;

carbon disulfide; In ethanol; water; at 100 ℃; for 0.166667h; Temperature; Time; Microwave irradiation;
DOI:10.3184/174751912X13400138806685

Reference yield:

: 1403889-20-2
4-(3,5-dichlorophenyl)-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1403889-33-7
4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 0.08 h / 90 °C / Microwave irradiation; Sealed tube

1.2: 0.17 h / 90 °C / Microwave irradiation; Sealed tube

2.1: hydrazine hydrate / ethanol / 0.17 h / 130 °C / Microwave irradiation; Sealed tube

3.1: potassium hydroxide / ethanol; water / 0.08 h / 100 °C / Microwave irradiation

3.2: 0.17 h / 100 °C / Microwave irradiation

With potassium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; water; acetone;
DOI:10.3184/174751912X13400138806685

Reference yield:

: 1403889-25-7
ethyl [4-(3,5-dichlorophenyl)-3-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate

: 1403889-33-7
4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 0.17 h / 130 °C / Microwave irradiation; Sealed tube

2.1: potassium hydroxide / ethanol; water / 0.08 h / 100 °C / Microwave irradiation

2.2: 0.17 h / 100 °C / Microwave irradiation

With hydrazine hydrate; potassium hydroxide; In ethanol; water;
DOI:10.3184/174751912X13400138806685