N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate

Base Information

• Chemical Name: N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate
• CAS No.: 130289-56-4
• Molecular Formula: C₃₃H₃₀ClNO₅
• Molecular Weight: 556.058
• Mol file: 130289-56-4.mol

Synonyms:N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate

Chemical Property of N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate

There total 2 articles about N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

dibenzyl L-glutamate (2768-50-5) + α,α-diphenyl-α-chloroacetic anhydride (103278-08-6) → N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate (130289-56-4)

Guidance literature:

In ethyl acetate; at 10 - 15 ℃;

DOI:10.1007/BF00766247

Reference yield:

chloro(diphenyl)acetic acid (7475-56-1) → N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate (130289-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.5 percent / PCl₅ / CHCl₃ / 1.) RT, 2 h, 2.) 100 deg C, 2 h

2: 92 percent / ethyl acetate / 10 - 15 °C

With phosphorus pentachloride; In chloroform; ethyl acetate;

DOI:10.1007/BF00766247

Reference yield:

N-(α,α-diphenyl-α-chloroacetyl)glutamic dibenzylate (130289-56-4) → N-(α,α-diphenyl-α-oxyacetyl)glutamic acid (130289-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) H₂₀, 2.) 5percent NaHCO₃ / 1.) reflux, 2 h, 2.) reflux, 0.5 h

2: 10percent acetic acid, H₂ / Pd/C / ethanol / 6 h

With water; hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1007/BF00766247

upstream raw materials:

dibenzyl L-glutamate

α,α-diphenyl-α-chloroacetic anhydride

chloro(diphenyl)acetic acid

Downstream raw materials:

N-(α,α-diphenyl-α-oxyacetyl)glutamic acid

Refernces