4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

Base Information

Chemical Name:4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine
CAS No.:1614246-05-7
Molecular Formula:C₂₂H₂₁FN₄O₃S
Molecular Weight:440.498
Hs Code.:

Synonyms:4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

There total 7 articles about 4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614246-33-1
2-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1614246-22-8
4-chloro-7-isopropyl-7H-imidazo[4,5-c]pyridazine

: 1614246-05-7
4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; at 20 - 110 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 351003-51-5
4-bromo-3-fluorobenzene-1-sulfonyl chloride

: 1614246-05-7
4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 18 h / Reflux

2.1: methanol / 1.5 h / 100 °C / Microwave irradiation

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 21 h / 20 °C / Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 3 h / 110 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / Reflux

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water / 1.5 h / 20 - 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1032825-02-7
1-bromo-2-fluoro-4-(methanesulfonyl)benzene

: 1614246-05-7
4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 1.5 h / 100 °C / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 21 h / 20 °C / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 3 h / 110 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / Reflux

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water / 1.5 h / 20 - 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; water;