1032825-02-7

Basic information

• Product Name: 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene
• Synonyms: 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene;Benzene, 1-broMo-2-fluoro-4-(Methylsulfonyl)-;1-broMo-2-fluoro-4-Methanesulfonylbenzene;4-Bromo-3-fluorophenyl methylsulfone;1-Bromo-2-fluoro-4-(methylsulfonyl)
• CAS NO: 1032825-02-7
• Molecular Formula: C₇H₆BrFO₂S
• Molecular Weight: 253.0887432
• Mol File: 1032825-02-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 348.3±42.0 °C(Predicted)
• Appearance: cream
• Density: 1.669±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene(1032825-02-7)
• EPA Substance Registry System: 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene(1032825-02-7)

Safety Data

• Hazardous Substances Data: 1032825-02-7(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-fluoro-4-(methylsulfonyl)benzene is a synthetic organic compound that belongs to the class of organosulfur compounds known as sulfonyls. It has bromo, fluoro and methylsulfonyl substituents on a benzene ring, which indicates it may demonstrate unique chemical properties resulting from these functional groups. 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene is typically utilized in research settings or for industry applications, often acting as an important intermediate in organic synthesis due to its distinctive chemical structure. However, its hazard classification, toxicological properties, and environmental impacts remain largely unclear, hence it should be handled with caution.

Upstream product

• 1620220-66-7 C₆H₆BrFN₂O₂S 
• 74-88-4 methyl iodide 
• 351003-51-5 4-bromo-3-fluorobenzene-1-sulfonyl chloride 
• 367-24-8 4-bromo-2-fluoroaniline 
• 917562-25-5 (4-bromo-3-fluorophenyl)(methyl)sulfane 
• 832755-13-2 2-fluoro-4-methanesulfonylaniline 

Downstream Products

• 1384951-71-6 2-(2-fluoro-4-methanesulfonylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1384951-03-4 7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine 
• 1384951-72-7 7-(2-fluoro-4-methanesulfonylphenyl)-4-(methylthio)thieno[3,2-d]pyrimidine 
• 1384951-73-8 7-(2-fluoro-4-methanesulfonylphenyl)-4-(methanesulfonyl)thieno[3,2-d]pyrimidine 
• 1384950-55-3 7-(2-fluoro-4-methanesulfonylphenyl)-4-[4-(3-isopropyl[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]thieno[3,2-d]pyrimidine 
• 1614246-05-7 4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-7-isopropyl-7H-imidazo[4,5-c]pyridazine 
• 1614246-09-1 7-cyclopentyl-4-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine 
• 90531-98-9 1-bromo-2-methoxy-4-(methylsulfonyl)benzene 
• 1614246-33-1 2-(6-fluoro-2'-methoxy-4'-(methylsulfonyl)[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1614246-31-9 2-(2-methoxy-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1415991-26-2 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-5-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole 
• 648904-85-2 2-(3-fluoro-4-methanesulfonyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 1258001-90-9 isopropyl 4-(5-cyano-4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]propyl}-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1258001-92-1 (E,Z)-isopropyl 4-(5-cyano-4-(2-(2-fluoro-4-(methylsulfonyl)phenyl)prop-1-enyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)

The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABAA ligand-gated ion channel are described. From a set of initial hits multiple subseries were designed and evaluated based on binding affinity and functional activity. As designing in the desired level of functional selectivity proved difficult, a probability-based assessment was performed to focus the project's efforts on a single subseries that had the greatest odds of delivering the target profile. These efforts ultimately led to the identification of two precandidates from this subseries, which were advanced to preclinical safety studies and subsequently to the identification of the clinical candidate PF-06372865.

NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS

The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of G protein-coupled receptors, particularly GPR119 G protein-coupled receptors.

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.