1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne

Base Information

• Chemical Name: 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne
• CAS No.: 1241905-97-4
• Molecular Formula: C₂₀H₁₉F₃O₅S
• Molecular Weight: 428.429
• Mol file: 1241905-97-4.mol

Synonyms:1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne

Chemical Property of 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne

There total 1 articles about 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5,5,5-trifluoro-2-phenyl-2-[(methoxy)methoxy]pent-3-yn-1-ol (1241905-93-0) + p-toluenesulfonyl chloride (98-59-9) → 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne (1241905-97-4)

Guidance literature:

With dmap; triethylamine; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.01.003

Reference yield: 78.0%

1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne (1241905-97-4) → 1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)penta-2,3-diene (1241906-04-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.01.003

Reference yield: 41.0%

1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)pent-2-yne (1241905-97-4) → C21H23F3O5S

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.01.003

upstream raw materials:

5,5,5-trifluoro-2-phenyl-2-[(methoxy)methoxy]pent-3-yn-1-ol

p-toluenesulfonyl chloride

Downstream raw materials:

1,1,1-trifluoro-5-[(methoxy)methoxy]-5-phenyl-4-(p-toluenesulfonyloxy)penta-2,3-diene

C₂₀H₂₁F₃O₆S