5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

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Chemical Name:5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol
CAS No.:216572-84-8
Molecular Formula:C₃₂H₄₂O₃SSi
Molecular Weight:534.835
Hs Code.:

Synonyms:5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

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Chemical Property of 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

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Technology Process of 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

There total 9 articles about 5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52753-91-0,132316-45-1
(E)-methyl 3-(2-formylphenyl)acrylate

: 216572-84-8
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 55 percent / NaBH₄ / methanol; H₂O / 2 h / 0 °C

2: 98 percent / dimethylformamide / 0.25 h / Ambient temperature

3: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4: PDC, mol. sieves 4A / CH₂Cl₂ / 1 h / Ambient temperature

5: Br₂ / CH₂Cl₂ / 0 °C

6: Et₃N / 2 h / Ambient temperature

7: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

8: tetrahydrofuran / -78 °C

With sodium tetrahydroborate; copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; bromine; diisobutylaluminium hydride; palladium; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01834-6

Reference yield:

: (E)-3-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-prop-2-en-1-ol

: 216572-84-8
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: PDC, mol. sieves 4A / CH₂Cl₂ / 1 h / Ambient temperature

2: Br₂ / CH₂Cl₂ / 0 °C

3: Et₃N / 2 h / Ambient temperature

4: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

5: tetrahydrofuran / -78 °C

With copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; bromine; palladium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)01834-6

Reference yield:

: 216572-78-0
3-(2-hydroxymethylphenyl)acrylic acid methyl ester

: 216572-84-8
5-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-11-methoxy-1-phenylsulfanyl-undeca-2,6-diyn-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / dimethylformamide / 0.25 h / Ambient temperature

2: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: PDC, mol. sieves 4A / CH₂Cl₂ / 1 h / Ambient temperature

4: Br₂ / CH₂Cl₂ / 0 °C

5: Et₃N / 2 h / Ambient temperature

6: 74 percent / Pd⁽⁰⁾-CuI(I), Et₃N / tetrahydrofuran / 1 h / Ambient temperature

7: tetrahydrofuran / -78 °C

With copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; bromine; diisobutylaluminium hydride; palladium; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01834-6