6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

Base Information

Chemical Name:6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene
CAS No.:124201-28-1
Molecular Formula:C₂₁H₂₇NO₅
Molecular Weight:373.449
Hs Code.:

Synonyms:6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

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Chemical Property of 6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

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Technology Process of 6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

There total 7 articles about 6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 64-17-5
ethanol

: 124201-27-0
4-(2-Carbomethoxyethyl)-5-<3,4-dimethoxy-6-(carbomethoxymethyl)phenyl>-4-nitrocyclohexene

: 124201-28-1
6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

Guidance literature:: With hydrogenchloride; zinc; for 15h; Heating;
DOI:10.1021/jo00291a029

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 124201-28-1
6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / conc. H₂SO₄ / 20 h / Heating

2: 78 percent / AlCl₃ / CH₂Cl₂ / 1) -5 deg C, 1 h, 2) 35 deg C, 30 min, 3) 20 deg C, 12 h

3: 74 percent / K₂CO₃, methylamine hydrochloride / methanol / 96 h / 20 °C

4: 74 percent / hydroquinone / toluene / 168 h / 135 °C

5: 87 percent / Triton-B / 2-methyl-propan-2-ol; tetrahydrofuran / 48 h / 20 °C

6: 91 percent / conc. HCl, zinc dust / 15 h / Heating

With hydrogenchloride; aluminium trichloride; methylamine hydrochloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; hydroquinone; zinc; sulfuric acid; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/jo00291a029

Reference yield:

: 15964-79-1
methyl (3,4-dimethoxyphenyl)acetate

: 124201-28-1
6-<3,4-Dimethoxy-6-(carbethoxymethyl)phenyl>-2-oxo-1-azaspiro<4.5>dec-8-ene

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / AlCl₃ / CH₂Cl₂ / -10 deg C to room temperature

2: 74 percent / K₂CO₃, MeNH₃Cl / methanol / 20 °C

3: 74 percent / hydroquinone, / toluene / 135 °C

4: 87 percent / Triton B / tetrahydrofuran; 2-methyl-propan-2-ol / 20 °C

5: 90 percent / Zn, HCl / Heating

With hydrogenchloride; aluminium trichloride; methylamine hydrochloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; hydroquinone; zinc; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1039/c39890001162