Technology Process of (R)-7-benzyloxymethyl-2,2-dimethyl-2,3,6,7-tetrahydro-[1,2]oxasilepine
There total 3 articles about (R)-7-benzyloxymethyl-2,2-dimethyl-2,3,6,7-tetrahydro-[1,2]oxasilepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
Heating;
DOI:10.1021/ja0037163
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / imidazole / dimethylformamide / 20 °C
2: 85 percent / Grubb's catalyst / CH2Cl2 / Heating
With
1H-imidazole;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0037163
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95.5 percent / copper(I) iodide / tetrahydrofuran / -78 - 0 °C
2: 99 percent / imidazole / dimethylformamide / 20 °C
3: 85 percent / Grubb's catalyst / CH2Cl2 / Heating
With
1H-imidazole; copper(l) iodide;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0037163
