4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

Base Information

Chemical Name:4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl
CAS No.:1057681-59-0
Molecular Formula:C₂₆H₂₃F₄N₃
Molecular Weight:453.482
Hs Code.:

Synonyms:4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

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Chemical Property of 4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

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Technology Process of 4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

There total 2 articles about 4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887418-66-8
4-(1H-indol-3-yl)-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2]-bipyridinyl

: 459-46-1
4-Fluorobenzyl bromide

: 1057681-59-0
4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 1.5h;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 17403-09-7
3-(4-piperidinyl)-1H-indole

: 1057681-59-0
4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-5'-trifluoromethyl-3,4,5,6-tetra-hydro-2H-[1,2]-bipyridinyl

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 - 95 °C

2: sodium hydroxide; tetra(n-butyl)ammonium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;