1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Base Information

Chemical Name:1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione
CAS No.:1376219-91-8
Molecular Formula:C₂₂H₃₀N₂O₉
Molecular Weight:466.488
Hs Code.:

Synonyms:1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

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Chemical Property of 1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

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Technology Process of 1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

There total 8 articles about 1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1-acetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

: 108-23-6
isopropyl chloroformate

: 1376219-91-8
1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 2.33333h; Cooling with ice;
DOI:10.1016/j.tet.2012.03.105

Reference yield:

: 1308721-86-9
2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde

: 1376219-91-8
1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 2.17 h / 25 °C

2.1: potassium tert-butylate / dichloromethane; tert-butyl alcohol / 2 h / 0 - 25 °C

3.1: 5% Rh/C; hydrogen / isopropyl alcohol / 14 h / 25 °C

4.1: dmap; triethylamine / dichloromethane / 2.33 h / 25 °C / Cooling with ice

With dmap; 5% Rh/C; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.03.105

Reference yield:

: 1376220-15-3
(3,4-dimethoxy-2-methylphenoxy)methyl methyl ether

: 1376219-91-8
1-acetyl-4-isopropyloxycarbonyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water / ethanol / 1.5 h / Reflux

2.1: acetic acid / 1 h / 125 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2.17 h / 25 °C

4.1: potassium tert-butylate / dichloromethane; tert-butyl alcohol / 2 h / 0 - 25 °C

5.1: 5% Rh/C; hydrogen / isopropyl alcohol / 14 h / 25 °C

6.1: dmap; triethylamine / dichloromethane / 2.33 h / 25 °C / Cooling with ice

With hydrogenchloride; dmap; 5% Rh/C; potassium tert-butylate; water; hydrogen; sodium hydride; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.03.105