tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Base Information

Chemical Name:tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate
CAS No.:1312770-05-0
Molecular Formula:C₂₈H₃₄ClN₃O₅S
Molecular Weight:560.114
Hs Code.:

Synonyms:tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Chemical Property of tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Technology Process of tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

There total 6 articles about tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312770-04-9
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

: 1312770-05-0
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In tetrahydrofuran; for 4h; Cooling with ice;

Reference yield:

: 1312770-03-8
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

: 1312770-05-0
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 72 h / 20 °C

2: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

With water; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1312769-68-8
tert-butyl 4-[(1S)-1-hydroxypropyl]benzoate

: 1312770-05-0
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice

3: triphenylphosphine; water / tetrahydrofuran / 16 h / 50 °C / Cooling with ice

4: sodium hydroxide / dichloromethane; water / 0.33 h / Cooling with ice

5: potassium tert-butylate / acetonitrile; tetrahydrofuran / 0.17 h / Cooling with ice

6: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 72 h / 20 °C

7: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

With sodium azide; potassium tert-butylate; water; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;