tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Base Information

Chemical Name:tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate
CAS No.:1312770-06-1
Molecular Formula:C₃₁H₄₁ClN₄O₆
Molecular Weight:601.143
Hs Code.:

Synonyms:tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Chemical Property of tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Technology Process of tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

There total 8 articles about tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312770-05-0
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

: 4490-81-7
isopropoxyamine hydrochloride

: 1312770-06-1
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: With mercury(II) diacetate; triethylamine; In tetrahydrofuran; methanol; for 0.333333h; Cooling with ice;

Reference yield:

: 1312769-69-9
tert-butyl 4-[(1R)-1-aminopropyl]benzoate

: 1312770-06-1
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / dichloromethane; water / 0.33 h / Cooling with ice

2: potassium tert-butylate / acetonitrile; tetrahydrofuran / 0.17 h / Cooling with ice

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 72 h / 20 °C

4: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

5: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 0.33 h / Cooling with ice

With potassium tert-butylate; mercury(II) diacetate; water; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1312769-67-7
tert-butyl 4-[(1R)-1-azidopropyl]benzoate

: 1312770-06-1
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(isopropoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; water / tetrahydrofuran / 16 h / 50 °C / Cooling with ice

2: sodium hydroxide / dichloromethane; water / 0.33 h / Cooling with ice

3: potassium tert-butylate / acetonitrile; tetrahydrofuran / 0.17 h / Cooling with ice

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 72 h / 20 °C

5: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

6: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 0.33 h / Cooling with ice

With potassium tert-butylate; mercury(II) diacetate; water; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;