Indole-6-boronic acid pinacol ester

Base Information

• Chemical Name: Indole-6-boronic acid pinacol ester
• CAS No.: 642494-36-8
• Molecular Formula: C14H18BNO2
• Molecular Weight: 243.113
• Hs Code.: 2934999090
• Mol file: 642494-36-8.mol

Synonyms:6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole;

Chemical Property of Indole-6-boronic acid pinacol ester

Chemical Property:

• Melting Point: 167-172 °C
• Boiling Point: 395.997 °C at 760 mmHg
• Flash Point: 193.292 °C
• PSA: 34.25000
• Density: 1.112 g/cm³
• LogP: 2.46710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Indole-6-boronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Indole-6-boronic acid, pinacol ester

Technology Process of Indole-6-boronic acid pinacol ester

There total 12 articles about Indole-6-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

→ 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-indole (642494-36-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 130 ℃; for 12h; Inert atmosphere;

Reference yield: 81.0%

6-fluoro-1H-indole (399-51-9) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-indole (642494-36-8)

Guidance literature:

With 2-((2,4,6-trimethylphenyl)amino)-4-((2,4,6-trimethylphenyl)imino)-2-pentene; magnesium; cobalt(II) chloride; In tetrahydrofuran; at 60 ℃; for 48h; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.8b03167

Reference yield: 78.0%

6-chloroindole (17422-33-2) + bis(pinacol)diborane (73183-34-3) → 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-indole (642494-36-8)

Guidance literature:

With potassium phosphate tribasic heptahydrate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; In ethanol; at 20 ℃; for 7h;

upstream raw materials:

6-bromo-1H-indole

bis(pinacol)diborane

1-bromo-4-methoxy-benzene

6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indole-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2-(1-(4-amino-3-(1H-indol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

5-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)-1H-indole

N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-2-fluoro-4-(1H-indol-6-yl)-N-methylbenzamide

N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4-(1H-indol-6-yl)benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 642494-36-8 Indole-6-boronic acid pinacol ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send