methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

Base Information

Chemical Name:methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate
CAS No.:1412975-77-9
Molecular Formula:C₂₈H₃₀FN₃O₇S
Molecular Weight:571.627
Hs Code.:

Synonyms:methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

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Chemical Property of methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

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Technology Process of methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

There total 8 articles about methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1412975-79-1
methyl 7-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxycarbonyl)amino]-1,2-dihydro-furo[2,3-c]quinoline-6-carboxylate

: 1412975-77-9
methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 60 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1055881-23-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-2-carbaldehyde

: 1412975-77-9
methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid / tetrahydrofuran / 24 h

3: pyridine / dichloromethane / 72 h / 20 °C

4: hydrogen; sodium hydride / tetrahydrofuran / 1 h / 20 °C

5: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 60 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; caesium carbonate; acetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1356112-00-9
methyl 7-aminofuro[2,3-c]quinoline-6-carboxylate

: 1412975-77-9
methyl 7-[N-{2-((Z)-3-diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid / tetrahydrofuran / 24 h

2: pyridine / dichloromethane / 72 h / 20 °C

3: hydrogen; sodium hydride / tetrahydrofuran / 1 h / 20 °C

4: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 60 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; acetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;