ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
CAS No.:853052-98-9
Molecular Formula:C₂₁H₁₈F₃N₃O₂
Molecular Weight:401.388
Hs Code.:

Synonyms:ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

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Chemical Property of ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

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Technology Process of ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

There total 3 articles about ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 853052-88-7
3-(ethylamino)-5-(trifluoromethyl)biphenyl-2,4-dicarbonitrile

: 105-36-2
ethyl bromoacetate

: ethyl 3-amino-7-cyano-1-ethyl-4-phenyl-6-(trifluoromethyl)-1H-indole-2-carboxylate

: 853052-98-9
ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; Heating;
DOI:10.1016/j.tet.2005.02.046

Reference yield:

: 853052-83-2
3-iodo-5-(trifluoromethyl)biphenyl-2,4-dicarbonitrile

: 853052-98-9
ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 6 h / 20 °C

2: 71 percent / potassium carbonate; potassium iodide / acetonitrile / Heating

With potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1016/j.tet.2005.02.046

Reference yield:

: 86439-16-9
3-trifluoromethyl-5-phenyl-2,6-dicyanoaniline

: 853052-98-9
ethyl 3-amino-7-cyano-1-ethyl-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaNO₂; HCl; KI / acetonitrile; H₂O / 0.5 h / 0 °C

1.2: 80 percent / acetonitrile; H₂O / 2 h / 20 °C

2.1: 70 percent / 6 h / 20 °C

3.1: 71 percent / potassium carbonate; potassium iodide / acetonitrile / Heating

With hydrogenchloride; potassium carbonate; potassium iodide; sodium nitrite; In water; acetonitrile;
DOI:10.1016/j.tet.2005.02.046