3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Base Information

Chemical Name:3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
CAS No.:331466-65-0
Molecular Formula:C₁₉H₁₁ClF₃N₃OS₂
Molecular Weight:453.896
Hs Code.:
European Community (EC) Number:649-003-4

Synonyms:3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide;KUC110268N;AKOS001644310;331466-65-0;KSC-230-157-1;EU-0042156;SR-01000467379;SR-01000467379-1;3-amino-N-(4-chlorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Suppliers and Price of 3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:452.9984165
Heavy Atom Count:29
Complexity:606

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CSC(=C1)C2=NC3=C(C(=C2)C(F)(F)F)C(=C(S3)C(=O)NC4=CC=C(C=C4)Cl)N

Technology Process of 3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

There total 5 articles about 3-amino-N-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 331466-62-7
N-(4-chloro-phenyl)-2-(3-cyano-6-thiophen-2-yl-4-trifluoromethyl-pyridin-2-ylsulfanyl)-acetamide

: 331466-65-0
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: With potassium carbonate; In ethanol; for 3h; Heating;

Reference yield:

: 104960-50-1
C₁₁H₅F₃N₂S₂

: 3289-75-6
2-chloro-N-(4-chlorophenyl)acetamide

: 331466-65-0
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: With potassium carbonate; In ethanol; at 90 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bioorg.2019.103269

Reference yield:

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 331466-65-0
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NEt₃ / ethanol / 2 h / Heating

2: 84 percent / NaOAc*3H₂O / ethanol / 4 h / Heating

3: 90 percent / K₂CO₃ / ethanol / 3 h / Heating

With sodium acetate; potassium carbonate; triethylamine; In ethanol; 3: Thorpe-Ziegler cyclization;