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Usage

Uses

Used in Polymer Production Industry:
TMPPO is used as a radical scavenger and stabilizer for preventing premature curing of unsaturated polyester resins. Its application ensures the stability of these resins during storage and processing, which is crucial for the production of high-quality polyester resins, adhesives, and coatings.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, the potential applications of TMPPO in the pharmaceutical sector suggest that it could be utilized as a component in the development of new drugs or as a stabilizing agent in pharmaceutical formulations to enhance their shelf life and efficacy.
Used in Chemical Industry for Material Development:
TMPPO's potential applications in the development of new materials within the chemical industry indicate that it may be employed in the synthesis of novel compounds or as a key component in the creation of advanced materials with unique properties.

Upstream product

• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 67-64-1 acetone 
• 63206-89-3 tris-2-oxypropylamine 

Downstream Products

• 36768-62-4 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE 
• 14691-88-4 tempamine 
• 14691-89-5 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl 
• 342630-78-8 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine 
• 159550-20-6 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine 
• 342630-68-6 3',5'-diisobutyryl-2-isobutyramido-N6-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine 
• 342630-70-0 5'-dimethoxytrityl-2-isobutyramido-N₆-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine 
• 342630-72-2 5'-dimethoxytrityl-2-isobutyramido-N₆-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine-3'-(2-cyanoethyl-N,Ndiisopropyl) phosphoramidite 
• 40908-37-0 N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide 
• 14691-89-5 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 132782-39-9 alpha-phenyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)nitrone 
• 83144-40-5 1-cyclohexyl-3-(2'.2'.6'.6'-tetramethyl-piperidin-4'-yl-1'-oxyl)-urea 
• 83144-39-2 2,2,6,6-tetramethyl-4-(3-methyl-3-nitrosoureido)piperidine-1-oxyl 

Relevant academic research and scientific papers

Synthesis and fluorescence properties of six fluorescein-nitroxide radical hybrid-compounds

Six fluorescein-nitroxide radical hybrid-compounds (2ab, 3ab, 4, and 5) were synthesized by the condensation of 5- or 6-carboxy-fluorescein and 4-amino-TEMPO (2ab), 5- or 6-aminofluorescein and 4-carboxy-TEMPO (3ab), and fluorescein and 4-carboxy-TEMPO (4), or by reaction of the 3-hydroxyl group of fluorescein with DPROXYL-3-ylmethyl methanesulfonate (5). Fluorescence intensities (around 520 nm) after reduction of the radical increased to 1.43-, 1.38-, and 1.61-folds for 2a, 2b and 3b respectively; 3a alone exhibited a decrease in intensity on reduction. Since 4 was readily solvolyzed in PBS or even methanol to afford fluorescein and 4-carboxy-TEMPO, its fluorescence change could not be measured. Hybrid compound 5 containing an ether-linkage between the fluorescein phenol and 3-hydroxymethyl-DPROXYL hydroxyl centers, was stable and on reduction, showed a maximum increase (3.21-fold) in relative fluorescence intensity in PBS (pH 5.0), despite its remarkably low absolute fluorescence intensity.

The mechanism of catalyst deactivation and by-product formation in acetone ammoximation catalyzed by hollow titanium silicalite

The deactivation mechanism of hollow titanium silicalite (HTS) in aqueous ammoximation of acetone was investigated. Amines and polynitro-compounds, formed by alkaline autocatalytic and oxidative coupling reaction respectively, were determined to be the ma

Selective synthesis of dimethyl ketone oxime through ammoximation over Ti-MOR catalyst

Titanosilicate with the MOR topology (Ti-MOR), postsynthesized from highly dealuminated mordenite and TiCl4 vapor through a solid–gas reaction, was highly active and selective for the liquid-phase ammoximation of dimethyl ketone (DMK) with ammonia and hydrogen peroxide. The parameters effecting the formation of the ammoximation product of dimethyl ketone oxime were investigated systematically in a batch-type reactor, and the optimized conditions were further applied to continuous ammoximation of DMK in a slurry reactor. Ti-MOR was superior to other titanosilicates in terms of activity and lifetime. TS-1 was not suitable for the ammoximation of DMK, whereas Ti-MWW required a higher catalyst loading to reach a reasonable activity, and they both easily produced a main byproduct of oxidative coupling of dimethyl ketone oxime. The deactivation behavior of Ti-MOR was investigated. Ammonia-induced structural desilication and accompanied Ti sites migration altered a more serious influence on the catalyst duration than coke deposition during continuous ammoximation.

Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: A different look of the ternary complex

Camptothecin (CPT) derivatives are clinically effective poisons of DNA topoisomerase I (Top1) able to form a ternary complex with the Top1-DNA complex. The aim of this investigation was to examine the dynamic aspects of the ternary complex formation by means of site-directed spin labeling electron paramagnetic resonance (SDSL-EPR). Two semisynthetic CPT derivatives bearing the paramagnetic moiety were synthesized, and their biological activity was tested. A 22-mer DNA oligonucleotide sequence with high affinity cleavage site for Top1 was also synthesized. EPR experiments were carried out on modified CPT in the presence of DNA, of Top1, or of both. In the last case, a slow motion component in the EPR signal appeared, indicating the formation of the ternary complex. Deconvolution of the EPR spectrum allowed to obtain the relative drug amounts in the complex. It was also possible to demonstrate that the residence time of CPT "trapped" in the ternary complex is longer than hundreds of microseconds.

Reactions of nitroxides. Part X: Antifungal activity of selected sulfur and selenium derivatives of 2,2,6,6-tetramethylpiperidine

The antifungal activity of nitroxyl radicals - derivatives of 2,2,6,6-tetramethylpiperidine-1-oxyl with reactive substituents 4-isothiocyanato-, 4-isocyano-, and 4-isoselenocyanato- and of N-formyl-, N-thioformyl-, N-selenoformyl-derivatives of 2,2,6,6-tetramethylpiperidine was investigated. Those of the above compounds, which contain a sulfur or selenium atom are the most active against four fungus plant patogens: Botrytis cinerea, Fusarium culmorum, Phytophthora cactorum, Rhizoctonia solani. 4-Isoselenocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl proved to be the most active compound.

PREPARATION OF 2,2,6,6-TETRAMETHYL-4-AMINOPIPERIDINE AND ITS SUBSTITUTED COMPOUNDS BY ELECTROREDUCTION OF AZOMETHINES OF 2,2,6,6-TETRAMETHYL-4-OXOPIPERIDINE (TRIACETONAMINE)

Five methods have been developed for electrosynthesis of 2,2,6,6-tetramethyl-4-aminopiperidine in 95 - 98 percent yield via the lead-cathode reduction of 2,2,6,6-tetramethyl-4-oxiimino-piperidine, a mixture of triacetonamine with inorganic salts of hydroxylamine, and a mixture of triacetonamine with nitric acid in a solution of sulphuric acid, via the reduction of azine triacetonamine and of a mixture of triacetonamine with inorganic salts of hydrazine in a neutral solution.The corresponding saturated derivatives of 2,2,6,6-tetramethyl-4-aminopiperidine have been obtained in 60 - 80 percent yield by ele ctroreduction of phenylimine and ethylene diimine.