(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Base Information

Chemical Name:(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol
CAS No.:192633-04-8
Molecular Formula:C₂₇H₄₆O₆Si
Molecular Weight:494.744
Hs Code.:

Synonyms:(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Suppliers and Price of (1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

There total 13 articles about (1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 192633-03-7
(2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanone

: 192633-04-8
(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(97)01069-1

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 192633-04-8
(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: i-Pr₂NEt

2: 1.) OsO₄, NMO; 2.) NaIO₄, NHCO₃ / 1.) CH₃CN, H₂O; 2.) 0 deg C

3: 98 percent / L-selectride / tetrahydrofuran / -78 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; L-Selectride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)01069-1

Reference yield:

: 100-39-0
benzyl bromide

: 192633-04-8
(1S,2S,3R,4R)-2-Benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-4-(2-trimethylsilanyl-ethoxymethoxymethyl)-cyclohexanol

Guidance literature:: Multi-step reaction with 10 steps

1: NaH / tetrahydrofuran; dimethylformamide / 0 °C

2: PCC / Ambient temperature

3: TsOH / acetone; H₂O

4: pyridine / Ambient temperature

5: 96 percent / NaBH₄ / methanol / 0 °C

6: 81 percent / t-BuOK, / 2-methyl-propan-2-ol / 1 h / 25 °C

7: 98 percent / NaBH₄ / methanol / 0 °C

8: i-Pr₂NEt

9: 1.) OsO₄, NMO; 2.) NaIO₄, NHCO₃ / 1.) CH₃CN, H₂O; 2.) 0 deg C

10: 98 percent / L-selectride / tetrahydrofuran / -78 °C

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; potassium tert-butylate; L-Selectride; sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)01069-1