Technology Process of Benzoic acid (2S,8R)-8-benzyloxy-2-methanesulfonyloxy-nonyl ester
There total 8 articles about Benzoic acid (2S,8R)-8-benzyloxy-2-methanesulfonyloxy-nonyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / 1.5 h / -15 °C
2: 2.25 g / pyridine / CH2Cl2 / 24 h / -15 - 20 °C
With
pyridine;
In
dichloromethane;
DOI:10.1021/jo0496392
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium / tetrahydrofuran
1.2: tetrahydrofuran / 0.5 h / 0 °C
1.3: 12.8 g / CuI / tetrahydrofuran / 15 h / 0 - 50 °C
2.1: 87 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 24 h / 0 - 20 °C
3.1: 44 percent / (R,R)-1,2-cyclohexanediamine based salen cobalt complex; acetic acid / toluene / 1 h / 20 °C
4.1: pyridine / CH2Cl2 / 1.5 h / -15 °C
5.1: 2.25 g / pyridine / CH2Cl2 / 24 h / -15 - 20 °C
With
pyridine; (R,R)-1,2-cyclohexanediamine based salen cobalt; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo0496392
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 94 percent / LiAlH4 / diethyl ether / 2 h / 0 °C
2.1: 77 percent / pyrdine / 3 h / 0 °C
3.1: magnesium / tetrahydrofuran
3.2: tetrahydrofuran / 0.5 h / 0 °C
3.3: 12.8 g / CuI / tetrahydrofuran / 15 h / 0 - 50 °C
4.1: 87 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 24 h / 0 - 20 °C
5.1: 44 percent / (R,R)-1,2-cyclohexanediamine based salen cobalt complex; acetic acid / toluene / 1 h / 20 °C
6.1: pyridine / CH2Cl2 / 1.5 h / -15 °C
7.1: 2.25 g / pyridine / CH2Cl2 / 24 h / -15 - 20 °C
With
pyridine; lithium aluminium tetrahydride; (R,R)-1,2-cyclohexanediamine based salen cobalt; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo0496392
