3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone

Base Information

• Chemical Name: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone
• CAS No.: 300718-32-5
• Molecular Formula: C₁₈H₁₂N₂OS
• Molecular Weight: 304.372
• Mol file: 300718-32-5.mol

Synonyms:3-phenyl-2-(thiophen-2-yl)quinazolin-4(3H)-one

Chemical Property of 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone

There total 3 articles about 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

thiophene-2-carbaldehyde (98-03-3) + 2-aminobenzanilide (4424-17-3) → 3-phenyl-2-(thiophen-2-yl)quinazolin-4(3H)-one (300718-32-5)

Guidance literature:

With tetrabutylammonium perchlorate; toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 1.5h; Electrolysis;

DOI:10.1002/adsc.201800927

Reference yield: 71.0%

thiophene-2-carbaldehyde (98-03-3) + isatoic anhydride (118-48-9) + aniline (62-53-3) → 3-phenyl-2-(thiophen-2-yl)quinazolin-4(3H)-one (300718-32-5)

Guidance literature:

With 1-(3-sulfopropyl)pyridinium phosphotungstate; dihydrogen peroxide; at 90 ℃; for 2h; Microwave irradiation;

Reference yield:

→ 3-phenyl-2-(thiophen-2-yl)quinazolin-4(3H)-one (300718-32-5)

Guidance literature:

In dimethyl sulfoxide; at 120 ℃; for 48h;

upstream raw materials:

thiophene-2-carbaldehyde

2-aminobenzanilide

isatoic anhydride

aniline

Refernces

• 1、 Cao, Liu,Huo, Hengrui,Zeng, Haipeng,Yu, Yu,Lu, Dengfu,Gong, Yuefa. "One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies". supporting information. p. 4764 - 4773. Retrieved 2018/11/10.
• 2、 Kim, Na Yeun,Cheon, Cheol-Hong. "Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO". supporting information. p. 2340 - 2344. Retrieved 2014/05/06.