Chemical Property of Mosapride citrate
Chemical Property:
- Appearance/Colour:white powder
- Vapor Pressure:4.11E-12mmHg at 25°C
- Melting Point:143-145°
- Boiling Point:549.2 °C at 760 mmHg
- Flash Point:286 °C
- PSA：227.41000
- LogP:2.62370
- Storage Temp.:Desiccate at RT
- Solubility.:DMSO (Slightly), Ethanol (Slightly, Sonicated)
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:13
- Rotatable Bond Count:12
- Exact Mass:613.1838501
- Heavy Atom Count:42
- Complexity:749
- Purity/Quality:
-
99% *data from raw suppliers
Mosapride citrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
- Recent ClinicalTrials:Efficacy Assessment of Chinese Herbal Medicine Tangweian Recipe Treating Participants With Diabetic Gastroenteropathy
- Recent NIPH Clinical Trials:A controlled study of efficacy and safety in CT colonography preparation with Mosapride Citrate Hydrate
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Description
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
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Uses
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia. A selective SR-4 activator and a SR-3 inhibitor Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.
