phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Base Information

Chemical Name:phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate
CAS No.:950676-32-1
Molecular Formula:C₂₂H₂₂F₃NO₆
Molecular Weight:453.415
Hs Code.:

Synonyms:phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

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Chemical Property of phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Chemical Property:

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Technology Process of phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

There total 5 articles about phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1885-14-9
phenyl chloroformate

: 640727-43-1
(Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol

: 950676-32-1
phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.tet.2007.04.097

Reference yield:

: 13230-71-2
N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 950676-32-1
phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.1 g / ICl / CH₂Cl₂ / 20 °C

2: 94 percent / CuI; Et₂NH / Pd(PPh₃)2Cl₂ / 20 °C

3: 97 percent / NaBH₄; H₂; ethylenediamine / Ni(OAc)2 / ethanol / 20 °C

4: 97 percent / pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; sodium tetrahydroborate; copper(l) iodide; hydrogen; Iodine monochloride; ethylenediamine; diethylamine; bis-triphenylphosphine-palladium(II) chloride; nickel diacetate; In ethanol; dichloromethane; 2: Sonogashira coupling;
DOI:10.1016/j.tet.2007.04.097

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 950676-32-1
phenyl (Z)-3-{4,5-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 2.1 g / ICl / CH₂Cl₂ / 20 °C

3: 94 percent / CuI; Et₂NH / Pd(PPh₃)2Cl₂ / 20 °C

4: 97 percent / NaBH₄; H₂; ethylenediamine / Ni(OAc)2 / ethanol / 20 °C

5: 97 percent / pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; sodium tetrahydroborate; copper(l) iodide; hydrogen; Iodine monochloride; ethylenediamine; diethylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; nickel diacetate; In ethanol; dichloromethane; 3: Sonogashira coupling;
DOI:10.1016/j.tet.2007.04.097