H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Base Information

Chemical Name:H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH
CAS No.:138541-36-3
Molecular Formula:C₇H₈O₃S*C₅₃H₈₅N₉O₁₄
Molecular Weight:1244.51
Hs Code.:

Synonyms:H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

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Chemical Property of H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

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Technology Process of H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

There total 4 articles about H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 104-15-4
toluene-4-sulfonic acid

: 138541-14-7
Z-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh

: 138541-36-3
H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Guidance literature:: With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 4h;

Reference yield:

: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

: 138541-36-3
H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaOH / dioxane; H₂O / 18 h / Ambient temperature

2: 80 percent / HOBt, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 1) pH 7, -20 deg C, 1 h, 2) rt, 24 h

3: 100 percent / H₂ / 10percent Pd/C / dimethylformamide / 4 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 4666-16-4
5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-2-{[(phenylmethoxy)carbonyl]amino}glutarate

: 138541-36-3
H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaOH / dioxane; H₂O / 18 h / Ambient temperature

2: 80 percent / HOBt, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 1) pH 7, -20 deg C, 1 h, 2) rt, 24 h

3: 100 percent / H₂ / 10percent Pd/C / dimethylformamide / 4 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;