(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

Base Information

Chemical Name:(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide
CAS No.:1278520-78-7
Molecular Formula:C₃₃H₃₀ClN₃O₃
Molecular Weight:552.072
Hs Code.:

Synonyms:(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

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Chemical Property of (S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

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Technology Process of (S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

There total 7 articles about (S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886225-49-6
(S)-biphenyl-2-carboxylic acid [3-chloro-4-(3-hydroxymethyl-2,3,4,5-tetrahydrobenzo[e][1,4]diazepine-1-carbonyl)-phenyl]-amide

: 106-95-6
allyl bromide

: 1278520-78-7
(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; Reflux;

Reference yield:

: 947-84-2
2-Biphenylcarboxylic acid

: 1278520-78-7
(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 5 - 20 °C

2.1: chloro-trimethyl-silane; pyridine / toluene / 0.5 h / 5 °C

2.2: 2.5 h / 5 °C

2.3: 35 - 85 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

3.2: 20 °C / Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.2: pH 7 - 8

5.1: potassium carbonate / acetonitrile / 20 °C / Reflux

With pyridine; hydrogenchloride; chloro-trimethyl-silane; thionyl chloride; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; acetic acid butyl ester; toluene; acetonitrile;

Reference yield:

: 4-[([1,1,-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoic Acid

: 1278520-78-7
(S)-N-(4-(4-allyl-3-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-1-carbonyl)-3-chlorophenyl)biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.2: pH 7 - 8

3.1: potassium carbonate / acetonitrile / 20 °C / Reflux

With hydrogenchloride; thionyl chloride; potassium carbonate; In 1,4-dioxane; acetic acid butyl ester; acetonitrile;