2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

Base Information

Chemical Name:2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one
CAS No.:1429043-88-8
Molecular Formula:C₁₆H₁₅F₃N₂O₄S
Molecular Weight:388.367
Hs Code.:

Synonyms:2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

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Chemical Property of 2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

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Technology Process of 2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

There total 4 articles about 2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1429043-76-4
N-benzyl-N-vinylisonicotinamide

: 1429043-88-8
2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol400571j

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1429043-88-8
2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / Inert atmosphere

2.1: pyridine / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Molecular sieve

2.2: 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tert-butyl alcohol / 60 h / 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 0 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; thionyl chloride; potassium tert-butylate; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol400571j

Reference yield:

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 1429043-88-8
2-benzyl-3-hydroxy-8-((trifluoromethyl)sulfonyl)-2,8-diazaspiro[4.5]deca-6,9-dien-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Molecular sieve

1.2: 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tert-butyl alcohol / 60 h / 20 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 0 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; potassium tert-butylate; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol400571j